Table 2: Association between neuropsychiatric CNVs and number of children.

From: Reproductive fitness and genetic risk of psychiatric disorders in the general population

CNVOdds ratio (autism/schizophrenia)Carriers (male/female)Non-carriers (male/female)Beta (male/female)P value (male/female)
All CNVs 201/26842,826/49,161−0.405/−0.1840.00028/0.050
Autism CNVs 37/6042,990/49,369−1.263/−0.4819.4E−07/0.014
Schizophrenia CNVs 189/25642,838/49,173−0.266/−0.1150.021/0.23
16p11.2 delinf/NA12/1243,015/49,417−2.534/−1.591.8E−08/0.00025
1q21.1 delNA/8.3511/1543,016/49,414−0.741/−0.980.12/0.012
22q11.21 delNA/inf392,453−1.4210.11
16p11.2 dup4.1/11.523992,417−0.3260.19
15q11.2—13.1 dupinf/13.20492,452−0.9260.23
7q11.23 (WBS) dupNA/11.35392,453−1.1500.23
15q13.3 all delinf/7.521992,437−0.3430.34
16p13.1 dupNA/2.3010392,353−0.1280.41
2p16.1 (NRXN1) del5.6/9.011192,445−0.3530.45
15q11.2 all delNA/2.1519292,264−0.0580.61
1q21.1 dupNA/3.453892,4180.0490.85
  1. Results are shown in males and females separately when there is a significant (P<0.05) association in either group. Counting all models fitted, 28 tests were performed; thus the significance threshold is P<0.0017. Odds ratios for autism and schizophrenia are from the literature7,8.