Table 2 Distinct structural properties of CLL BcR IGs homotypic interactions.

From: Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia

BcR IG (subset) BSA (Å2) N HB N SB BE (kcalmol1) Sc K D * (μM) koff (s1)
CLL183 (4) 558 5 4 −4.2 0.730 15.6±0.8 (1.99±0.09) × 10−5
CLL240 (4) 597 5 4 −5.1 0.724 14.0±0.4 (2.63±0.08) × 10−4
P11475 (2) 557 1 4 −0.2 0.680 430±160 >10−2
  1. BE, binding energy, computed from the experimental structures using the PISA server; BSA, buried surface area; KD, equilibrium dissociation constant; koff, dissociation kinetic rate constant; NHB and NSB, number of direct hydrogen bonds and salt bridges established at the protein–protein interface; Sc, surface complementarity.
  2. *Experimental values are shown as mean±s.d.
  3. Experimental values are shown as mean±s.d.