Figure 5: PHF5A-Y36C alters the effects of splicing modulators on MCL1 splicing. | Nature Communications

Figure 5: PHF5A-Y36C alters the effects of splicing modulators on MCL1 splicing.

From: Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

Figure 5

(a) Representative Sashimi plot of the production of different MCL1 isoforms under indicated treatment from either WT or Y36C PHF5A overexpressing cells. Total reads for each track are shown in the left. (b) Taqman gene expression analysis of indicated MCL1 isoforms in either WT (left panel) or Y36C (right panel) PHF5A expressing cells treated with splicing modulators. Error bar indicates s.d., n=2.

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