Figure 6 : AP+ pericytes contribution to skeletal muscle during chronic regeneration.

From: Pericytes resident in postnatal skeletal muscle differentiate into muscle fibres and generate satellite cells

Figure 6

(a,b) Triceps muscles of Tg:TN-AP-CreERT2:R26R:αSGKO (a) or Tg:TN-AP-CreERT2:R26R:αSG+/− (b) mice, injected with tamoxifen at P6–P8, killed two months later and stained for β-gal activity. Many β-gal+ fibres can be detected in the dystrophic muscle. (c) Muscle sections of Tg:TN-AP-CreERT2:R26R:αSGKO shown in (a) stained for β-gal and H&E. Scale bar, 100 μm. (d) Percentage of β-gal+ fibres detected in the dystrophic muscles. Grey bars indicate αSG+/− background; black bars indicate αSGKO background. Number of experimental animals: n=5; error bars indicate standard deviation. Results were assessed for statistical significance by Student's t-test (unpaired, two-tailed) and differences were considered statistically significant at P<0.05. Asterisks in the histogram indicate the P value: ***P<0.001. GAS, Gastrocnemius; TRIC, Triceps; PECT, Pectoralis; DIAPH, Diaphragm.