Abstract
Amide and olefins are important synthetic intermediates with complementary reactivity which play a key role in the construction of natural products, pharmaceuticals and manmade materials. Converting the normally highly stable aliphatic amides into olefins directly is a challenging task. Here we show that a Ni/NHC-catalytic system has been established for decarbonylative elimination of aliphatic amides to generate various olefins via C–N and C–C bond cleavage. This study not only overcomes the acyl C–N bond activation in aliphatic amides, but also encompasses distinct chemical advances on a new type of elimination reaction called retro-hydroamidocarbonylation. This transformation shows good functional group compatibility and can serve as a powerful synthetic tool for late-stage olefination of amide groups in complex compounds.
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Introduction
Aliphatic amide skeletons are key building blocks in a broad range of natural and artificial compounds such as proteins and nylons. Resonance stabilization of the amide bond confers stable characteristic in such compounds. Although amide C–N bonds can readily be cleaved by enzymes (Fig. 1a)1, transformations that allow direct functionalization of amide C–N bonds remains quite difficult. (Commonly used methods to cleave amide C–N bonds include the reductive conversion of amides to aldehydes using Schwartz’s reagent and the displacement of Weinreb’s N-OMe-N-Me amides with organometallic reagents en route to ketones2.) Elegant work by the groups of Garg and Houk has shown that nickel catalysis is effective to promote the conversion of amide derivatives to esters by acyl C–N bond activation (Fig. 1b)3,4,5,6. However, all these reported methods are limited to aryl and heteroaryl amide substrates7,8,9. Nevertheless, the development of catalytic system for the efficient transformation of amides derived from aliphatic carboxylic acids is still in high demand.
The alkene moiety is vital in many broad synthetic applications including Heck reaction, electrophilic addition and olefin metathesis reaction. The ability to interconvert other functional groups with alkene is significant in synthetic chemistry10. For instance, as the reverse reaction of hydrohalogenation11, regioselective dehydrohalogenations of alkyl bromides have been achieved in the presence of cobalt12 and palladium13 catalyst. Hydroformylation is an important homogeneously catalysed industrial process for the production of aldehydes from olefins14,15. In 2015, Dong and coworkers have disclosed rhodium-catalysed dehydroformylation of aldehyde substrates to olefins via transfer hydroformylation (Fig. 1c)16,17. Most recently, Morandi et al. have also achieved a remarkable interconversion between alkyl nitriles and alkenes by nickel-catalysed transfer hydrocyanation reactions (Fig. 1d)18. Inspired by these precedent results, a pathway involving decarbonylative elimination of aliphatic amides to olefin19 developed as the reverse conversion of hydroamidocarbonylation process20,21 seems meaningful to expand the synthetic utility (Fig. 1e).
To achieve this transformation, several difficulties need to be considered: (1) this transformation is to cleave a stable C–N bond while forming an easily transformable carbon–carbon double bond; (2) the C–N bond scission has a high activation energy and its selective cleavage in the presence of C–CN, C–O and C–F bonds is challenging; (3) the olefination products have a tendency to undergo decarbonylative Heck reaction with unconsumed amides22. Herein we disclose the first case of a retro-hydroamidocarbonylation process by chemoselective activation of aliphatic amide C–N bonds using nickel-catalysis23,24,25,26,27,28,29.
Results
Reaction design
We have recently reported nickel-catalysed decarbonylative cross-coupling of aryl amides to build C–B bonds30,31. As the key intermediate, the structure of the acyl nickel complex B (Ar=4-methyl-1-naphthyl) was first confirmed by X-ray analysis, which displayed the square planar geometry with two carbene (ICy: 1,3-dicyclohexylimidazol-2-ylidene) ligands mutually in trans position to each other. Furthermore, the decarbonylative product C was also confirmed by X-ray analysis. These findings uncovered key mechanistic features of the acyl C–N bond activation process (Fig. 2, left cycle). We proposed a similar acyl nickel species B′ as the key intermediate for further transformation in aliphatic amides. The intermediate B′, if formed, would undergo decarbonylation and a subsequent β-H elimination process would generate olefination products (Fig. 2,right cycle). Thus, an efficient retro-hydroamidocarbonylation process of aliphatic amides is theoretically possible.
Investigation of reaction conditions
Initial studies involved the evaluation of decarbonylative elimination of substrate 1 by acyl C–N bond activation (Table 1). This compound was chosen as the model substrate because of its structure, containing both ester32,33,34,35,36,37,38,39 and amide group, and selective activation of amide C–N bond was very meaningful. In the presence of 10 mol% Ni(COD)2, 20 mol% ICy·HCl, 20 mol% NaOtBu and 3.0 equiv K3PO4, at 130 °C under an argon atmosphere in toluene, we indeed observed the desired product 2 in 33% yield after 36 h in GC-MS (Table 1, entry 1). We further studied the performance of other NHC ligands such as IMes·HCl (Table 1, entry 2) and IPr·HCl (Table 1, entry 3) under these conditions and found that ICy·HCl promoted a dramatic reactivity for this transformation. It is noted that K2CO3 was slightly better than K3PO4 (Table 1, entry 4), and 44% yield of the desired product was observed by employing KOAc as the base (Table 1, entry 5). Under these conditions, changing the solvent to cyclohexane provided 51% yield of 2 (Table 1, entry 6). Using a binary solvent system, toluene and cyclohexane (v/v=1:2) resulted in 58% yield (Table 1, entry 7). Interestingly, more improvement could be achieved employing ICy as the ligand (Table 1, entry 8). To our delight, the utilization of 0.5 equiv Mg(OAc)2 as an additive exhibited higher reactivity and afforded olefin 2 in 83% yield without isomerization (Table 1, entry 9). Under these conditions, the reaction without KOAc or using other additives had shown inferior results (Table 1, entries 10–13). Notably, a lower loading of Ni(COD)2 can be employed with a slight decreasing in the reaction yield (Table 1, entry 14). Temperature effect was also examined, and decreasing the reaction temperature to 110 °C still resulted in an acceptable yield (Table 1, entry 15). Finally, other nickel sources such as anhydrous Ni(OAc)2 was proven completely unsuccessful in this reaction (Table 1, entry 16).
Scope of the methodology
With this exciting initial result in hand, we proceeded to investigate the scope of this reaction (Fig. 3). As shown, we have determined that this Ni-catalysed method can be applied to decarbonylative elimination of a series of aliphatic amides, furnishing the desired internal and terminal olefins in generally good yields. Cyclohexene derivatives with a wide array of functional groups including phenolic ester (4), N,N-dimethyl amide (6), benzylic ether (8) and pentyl group (10) can be synthesized in 55–74% yields without isomerizing to other positions. This result is noteworthy because of the known propensity of Ni–H intermediates to catalyse the rapid isomerization of alkenes leading to a mixture of products. N-benzoylpiperidine substrate 11 underwent olefination smoothly to provide the corresponding tetrahydropyridine 12 in good yield. Reaction of 13 containing two possible sites for β-hydride elimination gave regioisomeric olefins 14 and 14′ (2:1) in 75% combined yield, which were separable by column chromatography. Nonactivated, terminal aliphatic amide 15 was also very active substrates in the transformation and provided the desired olefin 16 in 63% yield. The substrate 17 with CN moiety could selectively generate the retro-hydroamidocarbonylation product 18 and the retrohydrocyanation product was not detected under our reaction conditions. The selectivity between the C–F and C–N bond was also investigated with a substrate 19, in which only C–N cleavage product 20 was observed. A secondary alkyl amide 21 underwent elimination, and produced the internal 2-alkene 22 in 62% yield with 77% selectivity. In addition, a wide range of styrene derivatives could be efficiently prepared by retro-hydroamidocarbonylation of the amides with secondary (23, 25), tertiary (27, 29, 31, 33, 35) and quaternary (37,39) α carbon centres in good yields. Among them, electronic effect favoured conjugated product 30 over terminal olefin. Elimination of 4-arylbutanoic acid amide 41 and 43 also exhibited the similar effect and generated E-olefins 42 and 44 by monoisomerization of the formed terminal products.
Fatty acids from animals, plants and microorganisms are a unique feedstock for the production of chemicals because of their characteristic long chain methylene sequences. We have transformed saturated fatty acids such namely myristic, and palmitic to corresponding amides and then subjected under the standard protocol to produce 2-alkenes 46 and 48 in 66% and 61% yields respectively with good selectivity. Impressively, unsaturated fatty acids such as erucic acid also participated in the reaction affording diene product 50 in 46% yield. Although it is reported that the strained ring of epoxides was easily opened in nickel catalytic systems, the substrate 51 with an epoxide group was found perfectly tolerable40. This nickel-catalysed retro-hydroamidocarbonylation was also viable with complex molecular precursors. The application of the present method resulted in the conversion of amide 53 containing a single γ C–H bond to terminal olefin 54 in 51% yield without isomerization. Moreover, through the use of a higher catalyst loading to 20 mol%, the yield could be improved to 66%. Based on the generated olefin group, 1,4-diol derivative was generated successfully via an iridium-catalysed tandam C–H silylation and oxidation reaction41. In case of the derivative of dehydrocholic acid 55 was performed, the corresponding terminal alkene 56 was also obtained selectively and further isomerization was negligible.
When primary alkyl halides, aldehydes and nitriles were used for transition-metal catalysed elimination, terminal alkenes were obtained as the main products13,14,17,19; remarkably, under our conditions, the thermodynamically more stable internal E-2-alkene isomers were mainly obtained from a tandem retro-hydroamidocarbonylation/monoisomerization process in substrates with amide groups adjacent to the secondary carbon centres42. It should be noted that the substituents at the γ position also has a large effect on this process. The aryl group at the γ position favours monoisomerization while the alkyl group inhibits the isomerization (44 versus 54 and 56).
Synthetic applications
To fully demonstrate the applicability of this methodology with predictable rules, we prepared a steroid product androstadienone (59), which was described to exhibit potent pheromone-like activities in human (Fig. 4)43. The synthesis commenced with the preparation of amide 58 from commercially available inexpensive etienic acid 57. By using retro-hydroamidocarbonylation as a key step, decarbonylative elimination of 58 afforded the costly androstadienone (59) in 43% yield without olefin-isomerization according to the rules outlined above. The formed double bond can be further functionalized to ketone to construct another compound Trichiliasterone B44. Since many methods have been developed to access N-Boc-N-Me amide groups, it allows facile application of the retro-hydroamidocarbonylation reaction to the laboratory-scale synthesis of nature products. A convincing example is using acrylamide 61 as a building block in construction of nature product skeleton. Starting from olefin 60 and acrylamide 61, we constructed substrate 62 via a reductive olefin coupling45. The decarbonylative elimination process could be applied to synthesize the key intermediate 63 in 70% yield as a core structure of aspewentin A, a norditerpene natural product isolated from Aspergillus wentii46,47.
Discussion
Several experiments were also conducted to provide insight about the potential mechanism of this transformation. As shown in Fig. 5a, radical clock substrate 64 generated the ring-open product 66 in 41% yield under the standard conditions, without detection of cyclopropane-containing product 65. Moreover, using the synthesized compound 65, it could not generate the diene product 66 in this Ni-catalysed system (Fig. 5b). These results demonstrated that this reaction proceed through a radical process. In addition, radical inhibiting experiments were carried out in the presence of radical traps (Fig. 5c). The reaction was largely inhibited when 0.2 equiv. TEMPO (the radical inhibitor TEMPO led to poor conversion, also presumably from catalyst inhibition48) or 2.0 equivalent BHT and DHA was added, also indicating a radical type reaction mechanism. This finding is inconsistent with the pathway we originally envisaged in Fig. 2. Because the C–N bond activation and decarbonylative process have been confirmed in our previous work30,31, we suspected that the formed intermediate C′ in aliphatic amides could occur homolytic cleavage reversibly49. Nonetheless, details for the mechanism of this reaction are not clear at present and more studies are required to fully elucidate the reaction mechanism.
In summary, we have developed an efficient Ni-catalysed system, which is capable of activating aliphatic amide C–N bonds for decarbonylative elimination to produce various olefins. (During the revision of this manuscript, Garg and coworkers reported Nickel-catalyzed C-N cleavage of aliphatic amides to construct esters50.) The application of this method to synthesize complex unsaturated molecules has also been illustrated. In view of the widespread utility of amide group, this method offers a very meaningful tool in synthetic transformation. Studies to determine further mechanistic details of this retro-hydroamidocarbonylation process and to expand the scope of aliphatic amide C–N bond activation to other transformations are underway in our laboratory.
Methods
General procedure (2)
To a 25 ml Schlenk flask equipped with a magnetic stir bar was charged with 0.2 mmol 4-((tert-butoxycarbonyl)(methyl)carb-amoyl)cyclohexane-1-carboxylate (1). The tube was introduced in nitrogen-filled glovebox, and Ni(COD)2 (5.5 mg, 10 mol %), ICy (9.3 mg, 20 mol %), KOAc (58.9 mg, 3.0 equiv), Mg(OAc)2 (14.2 mg, 0.5 equiv) were added. The tube with the mixture was taken out of the glovebox. Then cyclohexane (1.0 ml) and toluene (0.5 ml) were added under argon. The formed mixture was stirred at 130 °C under Ar for 36 h as monitored by TLC and GC-MS. The solution was then cooled to room temperature. The crude product was further purified by column chromatography on silica gel (n-pentane:AcOEt=50:1) to afford 20.2 mg (72%) of methyl cyclohex-3-ene-1-carboxylate (2) as a colourless oil. For NMR spectra of the compounds in this manuscript, see Supplementary Figs 1–127. For details of the synthetic procedures, see Supplementary Methods.
Data availability
The authors declare that the data supporting the findings of this study are available within the article and its Supplementary Information Files.
Additional information
How to cite this article: Hu, J. et al. Nickel-catalysed retro-hydroamidocarbonylation of aliphatic amides to olefins. Nat. Commun. 8, 14993 doi: 10.1038/ncomms14993 (2017).
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References
Negoro, S. Biodegradation of nylon oligomers. Appl. Microbiol. Biotechnol. 54, 461–466 (2000).
Nahm, S. & Weinreb, S. M. N-Methoxy-N-methylamides as effective acylating agents. Tetrahedron Lett. 22, 3815–3818 (1981).
Hie, L. et al. Conversion of amides to esters by the nickel-catalysed activation of amide C–N bonds. Nature 524, 79–83 (2015).
Baker, E. L., Yamano, M. M., Zhou, Y., Anthony, S. M. & Garg, N. K. A two-step approach to achieve secondary amide transamidation enabled by nickel catalysis. Nat. Commun. 7, 11554 (2016).
Weires, N. A., Baker, E. L. & Garg, N. K. Nickel-catalysed Suzuki–Miyaura coupling of amides. Nat. Chem. 8, 75–79 (2016).
Simmons, B. J., Weires, N. A., Dander, J. E. & Garg, N. K. Nickel-catalyzed alkylation of amide derivatives. ACS Catal. 6, 3176–3179 (2016).
Li, X. & Zou, G. Acylative Suzuki coupling of amides: acyl-nitrogen activation via synergy of independently modifiable activating groups. Chem. Commun. 51, 5089–5092 (2015).
Yada, A., Okajima, S. & Murakami, M. Palladium-catalyzed intramolecular insertion of alkenes into the carbon-nitrogen bond of β-lactams. J. Am. Chem. Soc. 137, 8708–8711 (2015).
Shi, S., Meng, G. & Szostak, M. Synthesis of biaryls through nickel-catalyzed Suzuki–Miyaura coupling of amides by carbon–nitrogen bond cleavage. Angew. Chem., Int. Ed. 55, 6959–6963 (2016).
Bhawal, B. N. & Morandi, B. Catalytic transfer functionalization through shuttle catalysis. ACS Catal. 6, 7528–7535 (2016).
Ananikov V. P., Tanaka M. eds Hydrofunctionalization Springer-Verlag (2013).
Kobayashi, T., Ohmiya, H., Yorimitsu, H. & Oshima, K. Cobalt-catalyzed regioselective dehydrohalogenation of alkyl halides with dimethylphenylsilylmethylmagnesium chloride. J. Am. Chem. Soc. 130, 11276–11277 (2008).
Bissember, A. C., Levina, A. & Fu, G. C. A mild, palladium-catalyzed method for the dehydrohalogenation of alkyl bromides: synthetic and mechanistic studies. J. Am. Chem. Soc. 134, 14232–14237 (2012).
Franke, R., Selent, D. & Börner, A. Applied hydroformylation. Chem. Rev. 112, 5675–5732 (2012).
Hebrard, F. & Kalck, P. Cobalt-catalyzed hydroformylation of alkenes: generation and recycling of the carbonyl species, and catalytic cycle. Chem. Rev. 109, 4272–4282 (2009).
Murphy, S. K., Park, J.-W., Cruz, F. A. & Dong, V. M. Rh-catalyzed C–C bond cleavage by transfer hydroformylation. Science 347, 56–60 (2015).
Kusumoto, S., Tatsuki, T. & Nozaki, K. The retro-hydroformylation reaction. Angew. Chem., Int. Ed. 54, 8458–8461 (2015).
Fang, X., Yu, P. & Morandi, B. Catalytic reversible alkene-nitrile interconversion through controllable transfer hydrocyanation. Science 351, 832–836 (2016).
Meng, G. & Szostak, M. Sterically controlled Pd-catalyzed chemoselective ketone synthesis via N-C cleavage in twisted amides. Org. Lett. 17, 4364–4367 (2015).
Dong, K. et al. Rh(I)-catalyzed hydroamidation of olefins via selective activation of N–H bonds in aliphatic amines. J. Am. Chem. Soc. 137, 6053–6058 (2015).
Li, H., Dong, K., Neumann, H. & Beller, M. Palladium-catalyzed hydroamidocarbonylation of olefins to imides. Angew. Chem., Int. Ed. 54, 10239–10243 (2015).
Meng, G. & Szostak, M. General olefin synthesis by the palladium-catalyzed heck reaction of amides: sterically controlled chemoselective N–C activation. Angew. Chem., Int. Ed. 54, 14518–14522 (2015).
Moragas, T., Gaydou, M. & Martin, R. Nickel-catalyzed carboxylation of benzylic C-N bonds with CO2 . Angew. Chem., Int. Ed. 55, 5053–5057 (2016).
Yi, Y.-Q.-Q. et al. Nickel-catalyzed C–N bond reduction of aromatic and benzylic quaternary ammonium triflates. Chem. Commun. 52, 10894–10897 (2016).
Basch, C. H., Cobb, K. M. & Watson, M. P. Nickel-catalyzed borylation of benzylic ammonium salts: stereospecific synthesis of enantioenriched benzylic boronates. Org. Lett. 18, 136–139 (2016).
Zhang, H., Hagihara, S. & Itami, K. Making dimethylamino a transformable directing group by Nickel-catalyzed C–N borylation. Chem. Eur. J. 21, 16796–16800 (2015).
Hu, J. et al. Nickel-catalyzed borylation of aryl- and benzyltrimethylammonium salts via C–N bond cleavage. J. Org. Chem. 81, 14–24 (2016).
Tobisu, M., Nakamura, K. & Chatani, N. Nickel-catalyzed reductive and borylative cleavage of aromatic carbon-nitrogen bonds in N-aryl amides and carbamates. J. Am. Chem. Soc. 136, 5587–5590 (2014).
Maity, P., Shacklady-McAtee, D. M., Yap, G. P. A., Sirianni, E. R. & Watson, M. P. Nickel-catalyzed cross couplings of benzylic ammonium salts and boronic acids: stereospecific formation of diarylethanes via C-N bond activation. J. Am. Chem. Soc. 135, 280–285 (2013).
Hu, J., Zhao, Y., Liu, J., Zhang, Y. & Shi, Z. Nickel-catalyzed decarbonylative borylation of amides: evidence for acyl C-N bond activation. Angew. Chem., Int. Ed. 55, 8718–8722 (2016).
Pu, X., Hu, J., Zhao, Y. & Shi, Z. Nickel-catalyzed decarbonylative borylation and silylation of esters. ACS Catal. 6, 6692–6698 (2016).
Guo, L., Chatupheeraphat, A. & Rueping, M. Decarbonylative silylation of esters by combined nickel and copper catalysis for the synthesis of arylsilanes and heteroarylsilanes. Angew. Chem., Int. Ed. 55, 11810–11813 (2016).
Hie, L. et al. Nickel-catalyzed activation of acyl C–O bonds of methyl esters. Angew. Chem., Int. Ed. 55, 2810–2814 (2016).
Muto, K., Yamaguchi, J., Musaev, D. G. & Itami, K. Decarbonylative organoboron cross-coupling of esters by nickel catalysis. Nat. Commun. 6, 7508–7515 (2016).
Hong, X., Liang, Y. & Houk, K. N. Mechanisms and origins of switchable chemoselectivity of Ni-catalyzed C(aryl)-O and C(acyl)-O activation of aryl esters with phosphine ligands. J. Am. Chem. Soc. 136, 2017–2025 (2014).
Lu, Q., Yu, H. & Fu, Y. Mechanistic study of chemoselectivity in Ni-catalyzed coupling reactions between azoles and aryl carboxylates. J. Am. Chem. Soc. 136, 8252–8260 (2014).
Meng, L., Kamada, Y., Muto, K., Yamaguchi, J. & Itami, K. C-H Alkenylation of azoles with enols and esters by nickel catalysis. Angew. Chem., Int. Ed. 52, 10048 (2013).
Correa, A., Cornella, J. & Martin, R. Nickel-catalyzed decarbonylative C-H coupling reactions: A strategy for preparing bis(heteroaryl) backbones. Angew. Chem., Int. Ed. 52, 1878 (2013).
Amaike, K., Muto, K., Yamaguchi, J. & Itami, K. Decarbonylative C–H coupling of azoles and aryl esters: unprecedented nickel catalysis and application to the synthesis of Muscoride A. J. Am. Chem. Soc. 134, 13573–13576 (2012).
Molinaro, C. & Jamison, T. F. Nickel-catalyzed reductive coupling of alkynes and epoxides. J. Am. Chem. Soc. 125, 8076–8077 (2003).
Ghavtadze, N., Melkonyan, F. S., Gulevich, A. V., Huang, C. & Gevorgyan, V. Conversion of 1-alkenes into 1,4-diols through an auxiliary-mediated formal homoallylic C-H oxidation. Nat. Chem. 6, 122–125 (2016).
Larsen, C. R., Erdogan, G. & Grotjahn, D. B. General catalyst control of the monoisomerization of 1-alkenes to trans-2-alkenes. J. Am. Chem. Soc. 136, 1226–1229 (2014).
Wyart, C. et al. Smelling a single component of male sweat alters levels of cortisol in women. J. Neurosci. 27, 1261–1265 (2007).
Hantos, S. M., Tripathy, S., Alibhai, N. & Durst, T. Synthesis of trichiliasterones A and B, 16-Ketosteroids isolated from Trichilia hirta and Trichilia americana. Can. J. Chem. 79, 1747–1753 (2001).
Lo, J. C., Yabe, Y. & Baran, P. S. A practical and catalytic reductive olefin coupling. J. Am. Chem. Soc. 136, 1304–1307 (2014).
Miao, F.-P., Liang, X.-R., Liu, X.-H. & Ji, N.-Y. Aspewentins A-C, norditerpenes from a cryptic pathway in an algicolous strain of Aspergillus wentii. J. Nat. Prod. 77, 429–432 (2014).
Liu, Y., Virgil, S. C., Grubbs, R. H. & Stoltz, B. M. Palladium-catalyzed decarbonylative dehydration for the synthesis of α-vinyl carbonyl compounds and total synthesis of (-)-Aspewentins A, B, and C. Angew. Chem., Int. Ed. 54, 11800–11803 (2015).
Kadunce, N. T. & Reisman, S. E. Nickel-catalyzed asymmetric reductive cross-coupling between heteroaryl iodides and α-chloronitriles. J. Am. Chem. Soc. 137, 10480–10483 (2015).
Rettenmeier, C. A., Wenz, J., Wadepohl, H. & Gade, L. H. Activation of aryl halides by nickel(I) pincer complexes: reaction pathways of stoichiometric and catalytic dehalogenations. Inorg. Chem. 55, 8214–8224 (2016).
Hie, L. et al. Nickel-catalyzed esterification of aliphatic amides. Angew. Chem., Int. Ed. 55, 15129–15132 (2016).
Acknowledgements
We thank the ‘1000-Youth Talents Plan’, the ‘Jiangsu Specially-Appointed Professor Plan’, NSF of China (Grant 21402086, 21672097) and NSF of Jiangsu Province (Grant BK20140594) for financial support. This work was also supported by a Supported by the program for Outstanding PhD candidate of Nanjing University.
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J.H. and X.P. performed the experiments. Z.S. conceived the concept, directed the project and wrote the paper. M.W. and Z.S. discussed the results and commented on the manuscript.
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Hu, J., Wang, M., Pu, X. et al. Nickel-catalysed retro-hydroamidocarbonylation of aliphatic amides to olefins. Nat Commun 8, 14993 (2017). https://doi.org/10.1038/ncomms14993
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DOI: https://doi.org/10.1038/ncomms14993
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