Figure 5 : Inferior lateral prefrontal activity correlates with the demands of a breadth-first search at Detours.

From: Hippocampal and prefrontal processing of network topology to simulate the future

Figure 5

(a) Diagrams of an example street network contrasting scenarios of lower and higher demand breadth-first search. Breadth-first search assumes the search space (street segments) as a tree and considers all possible solutions within one level before proceeding to the subsequent level. In these diagrams, covering the first layer of the search, the lower demand scenario shows less possible paths, while the higher demand scenario shows a greater number of possible paths. For details see Methods. (b) The statistical parametric map showing correlation (P<0.05 FWE-corrected) of the left and right lateral PFC with planning demands for the first layer of the decision tree (Navigation>Control). We found bilateral lateral PFC activity correlated with planning demands (P<0.001 uncorrected) during Detours in navigation routes, but not in control routes. We found no significant correlations when the planning demands of first and second layer combined were entered in the analysis. The statistical parametric maps are displayed on the mean structural image at a threshold of P<0.005 uncorrected and five voxels minimum cluster size. See Supplementary Table 11 for details of activations. Comparison of parameter estimates of peak voxel in the right lateral PFC showed a significantly greater response at Detours compared with Decision Points (t23=3.49, P=0.002).