Figure 4: NEKO mice display bilateral hydronephrosis. | Nature Communications

Figure 4: NEKO mice display bilateral hydronephrosis.

From: Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus

Figure 4

(ad) Representative images of haematoxylin and eosin (HE) staining of coronal kidney sections of control and NEKO mice at 8 weeks (a,b) and 10 days (c,d) of age (n=4). Scale bar, 100 μm. (e) Urine volume of control and NEKO mice at 4 weeks of age. (**P<0.01, unpaired t-test). (fi) Periodic acid-Schiff staining of renal outer medulla (f,g) and HE staining of renal cortex (h,i) of control and NEKO mice at 8 weeks of age. Open and closed arrowheads indicate dilated collecting ducts and inflammatory cell infiltration, respectively. Open and closed arrows indicated normal and damaged glomerulus, respectively. Scale bar, 10 μm. (j) Plasma blood urea nitrogen level in control and NEKO mice at 8–12 weeks of age. (**P<0.01, unpaired t-test). (k,l) Ink infused into the pyelocaliceal space of the kidney of control and NEKO mice at 8 weeks of age. (m) Urinary bladder (B) and kidney (K) of control and NEKO mice at 8 weeks of age. Scale bar, 5 mm.

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