(a) Representative digital micrograph area of negatively stained DegP12 and DegP24-loaded DNA cages. Scale bar, 100 nm. Representative class averages, each containing ∼50–100 particles, for DegP6 (b), DegP12 (c) and DegP24 (d). Scale bar, 10 nm. The simulated 3D models from the respective crystal structures downfiltered to a resolution of 15 Å are also indicated. PDB-ID codes for DegP6 (b), DegP12 (c) and DegP24 (d) are, respectively, 1ky9, 2zle and 3cS0. Two-dimensional analysis of empty (e), DegP6 (f), DegP12 (g) and DegP24 (h) loaded DNA origami hosts bearing 18 convergent PAs in their cavity (6p120-18cA1). Representative class averages, each containing ∼25–100 particles, and raw particle images of the corresponding classes are reported, together with a model of each construct, both in top and front view. Scale bar, 10 nm.