Figure 3: Immunization with Tp0751 inhibits T. pallidum dissemination. | Nature Communications

Figure 3: Immunization with Tp0751 inhibits T. pallidum dissemination.

From: A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum

Figure 3

T. pallidum burden was evaluated in control (Ct, N=2) and immunized (Im, N=3) animals using quantitative real-time PCR to measure flaA DNA concentrations in lesion biopsies ((a); local infection site) and in disseminated infection sites, (b) bone, (c) liver and (d) spleen. Results were normalized to rabbit gDNA concentration and presented as median±interquartile range (IQR); points correspond to separately extracted samples from each animal. (e) Total disseminated burden was assessed between control animals (n=6 samples, 3 samples per animal) and immunized animals (n=9 samples) across all disseminated sites (bone, blue; liver, orange; spleen, purple) using Mann–Whitney test (**P<0.005).

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