Figure 7: SNAIL is a functional target of HOPX in the regulation of EMT and metastasis of NPC cells. | Nature Communications

Figure 7: SNAIL is a functional target of HOPX in the regulation of EMT and metastasis of NPC cells.

From: HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma

Figure 7

Vector2 (V2) or SNAIL was transfected in CNE2 and SUNE1 cells that stably overexpressed the vector (V) or HOPX. (ac) The migration and invasion abilities were measured using wound healing assays (× 200) (a) and Transwell assays (× 200) without (b) or with (c) Matrigel. Scale bar, 100 μm; mean±s.d.; *P<0.01 compared with V+V2; #P<0.01 compared with the HOPX+V2; Student’s t-tests. (d) ECADHERIN, VIMENTIN, SNAIL, HOPX and GAPDH expression levels were measured via western blotting. These data are representative of three independent experiments.

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