Figure 9 : SREBP1c-CRY1 axis suppresses hepatic gluconeogenesis by promoting FOXO1 degradation.

From: SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding

Figure 9

For long-term insulin action, SREBP1c-CRY1 axis suppresses hepatic gluconeogenesis through nuclear FOXO1 degradation. During anabolic state, increased CRY1 accelerates MDM2-mediated FOXO1 degradation and thereby insulin sustainably represses hepatic glucose production.