Figure 1: Overall characterization of SCNAs in TCGA and plasma samples. | Nature Communications

Figure 1: Overall characterization of SCNAs in TCGA and plasma samples.

From: Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer

Figure 1

(a) Circos plot illustrating the relative frequency of SCNAs (gains in red and losses in blue) of 493 prostate cancer cases from the TCGA database (inner circle) and 95 plasma samples from patients with metastasized prostate cancer (middle circle). The outer circle shows ideograms of the respective chromosomes. (b) Partial chromosome 5 circos plot of plasma samples without (inner segment) and with (middle segment) TMPRSS2:ERG fusion, the ellipse marks the CHD1 region. (c) Scatter plot of 30 genes commonly involved in amplifications (left panel; green bar: 20 Mb; red bar: copy number of 4) and 42 genes frequently involved in focal deletions (right panel; green bar: 20 Mb; red bar: copy number of 1) derived from 5,737 cases of the TCGA pan-cancer data set demonstrating an inverse relationship between amplification and deletion size, respectively, as well as copy numbers.

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