Figure 8 : Summary model of spatial dynamics of seizure evolution and termination.

From: The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures

Figure 8

(a) Schematic showing snapshots of seizure progression through the four seizure epochs. Colours represent the spatial organization of the epochs shown in time series data of Fig. 1. Dashed-line squares represent the MEA footprint, and dashed-line circles represent ECoG electrodes. Yellow ECoG electrodes represent those exhibiting hypersynchronous ictal activity in the low-frequency (0.3–50 Hz) LFP. As the recruited region (seizure core) gradually expands to envelope the MEA site, the ictal wavefront approaches the site, passes through it and then continues to move away from the site. (b) Schematic depictions of travelling wave activity across the MEA microelectrodes during each of the four seizure epochs. Rapidly moving travelling waves across the MEA change direction based on the MEAs location relative to the slowly moving ictal wavefront.