Figure 5 : Decreasing input to a network of simulated neurons recreates mean-field dynamics observed in the data.

From: The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures

Figure 5

(a) Mean firing rate of the simulated ictal network progresses from tonic firing, to rhythmic discharging, to self-termination, with decreasing extra-network input. The colours correspond to the epochs labelled in Fig. 1 as apparent in the model’s firing rate. (b) Firing rate from all microelectrode channels during one spontaneous human seizure, showing the progression from tonic firing during ictal wavefront passage, to rhythmic discharging, to seizure termination. The coloured bars above the seizures correspond to the epochs labelled in Fig. 1. (c) Peak mean firing rate during each discharge in the pre-termination period for the simulated neurons (green) and the seizure shown in b (purple). (d) Inter-discharge intervals during the pre-termination period, for the simulated neurons (green) and the seizure shown in b (purple). (e) Discharge width during the pre-termination period, for the simulated neurons (green) and the seizure shown in b (purple).