Figure 1 : Progression of seizure activity recorded from a microelectrode array in the ictal core.

From: The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures

Figure 1

Colours indicate the different epochs in the seizure: light blue is the pre-recruitment epoch, orange is the ictal wavefront epoch, purple is the post-recruitment epoch and pink is the pre-termination epoch. Seizure termination is labelled with a dark blue dotted line. (a) Cartoon of hypothesized spatial organization of seizure activity relative to the microelectrode array (MEA) location. (b) Raw LFP traces recorded from a single microelectrode during a seizure. (c) Averaged firing rate over electrodes on the array during the seizure in b. (d) Multiunit raster plot over MEA channels during the seizure in b. (e) Inter-discharge intervals (IDIs) for each discharge through the duration of the same seizure. The abrupt transition from regular to irregular IDIs at 36 s after seizure onset marks the transition from post-recruitment (period following passage of the ictal wavefront) to the pre-termination epoch. In both b and c, the abrupt cessation of discharges in both LFP and MUA, which is the defining event marking seizure termination, is evident.