Figure 1 : MML-1/MXL-2 are required for multiple longevity pathways.

From: Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals

Figure 1

(a) glp-1(e2141) suppressor screens identify mml-1 and mxl-2 as new transcription factors required for gonadal longevity. Survivorship of glp-1(e2141) worms on control RNAi (L4440, black arrow) and experimental RNAi was determined at day 25. Knockdown of known factors (for example, daf-16, daf-12 and hlh-30), as well as mml-1 and mxl-2, completely suppressed glp-1 survivorship. Survivorship of 60 worms was determined and screening conducted twice. (b) C. elegans Myc superfamily comprises MML-1/MXL-2 and MDL-1/MXL-1 complexes. (c–g) Roles of mml-1 and mxl-2 in various longevity pathways. mml-1(ok849) and mxl-2(tm1516) deletions suppress longevity of germline-deficient glp-1(e2141) mutants (c) and animals with germline laser microsurgery (d). mml-1 and mxl-2 suppress longevity of daf-2 RNAi (e). mml-1 is required for isp-1 (qm150) longevity (f) but not required for the longevity conferred by cco-1 RNAi (g). mxl-2 is not specifically required for isp-1 or cco-1 RNAi longevity (f,g). See Supplementary Table 1 for details and repeats.