Figure 1: Overview of phenome data for the BXD cohort. | Nature Communications

Figure 1: Overview of phenome data for the BXD cohort.

From: Joint mouse–human phenome-wide association to test gene function and disease risk

Figure 1

(a) Five pairs of isogenic BXD cohort strains—BXD43 to BXD102. There are now approximately 100 readily available BXD strains and another 50 that are almost fully inbred. Almost all current phenome data is restricted to the parents, F1 hybrids (B6D2F1 and D2B6F1) and BXD1 through BXD102. (b) Phenome data categorized by type, including classic phenotypes (top and see comprehensive definitions in Supplementary Data 1), metabolic and proteomic trait data (middle), and independent mRNA expression assays (bottom, n=86 unique eQTL data sets, see Supplementary Note 1 Summary Expression Phenome). (c) Body weight data for BXD strains on high-fat (grey) and low-fat (black) diets taken from Wu et al.10. (d) Expression of Bckdhb mRNA and its protein in six tissues for the five BXD strains. Protein data from Wu et al.10

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