Membrane lipids function as structural molecules, reservoirs for second messengers, membrane platforms that scaffold protein assembly and regulators of enzymes and ion channels. Such diverse lipid functions contribute substantially to cellular mechanisms for fine-tuning membrane-signaling events. Meaningful coordination of these events requires exquisite spatial and temporal control of lipid metabolism and organization, and reliable mechanisms for specifically coupling these parameters to dedicated physiological processes. Recent studies suggest such integration is linked to the action of phosphatidylinositol transfer proteins that operate at the interface of the metabolism, trafficking and organization of specific lipids.
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This work was supported by grants from the US National Institutes of Health to V.A.B. K.E.I. and G.S. were also supported by a Predoctoral Training Grant from the US National Institutes of Health and a Postdoctoral Fellowship from the Deutsche Forschungsgemeinschaft, respectively.
The authors declare no competing financial interests.
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Ile, K., Schaaf, G. & Bankaitis, V. Phosphatidylinositol transfer proteins and cellular nanoreactors for lipid signaling. Nat Chem Biol 2, 576–583 (2006). https://doi.org/10.1038/nchembio835
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