Sir2 is a key regulator in promoting longevity in response to a low-calorie diet. A new role for nitric oxide in promoting mitochondrial synthesis may be the reason why.
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Guarente, L. NO link between calorie restriction and mitochondria. Nat Chem Biol 1, 355–356 (2005). https://doi.org/10.1038/nchembio1205-355
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