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NO link between calorie restriction and mitochondria

Sir2 is a key regulator in promoting longevity in response to a low-calorie diet. A new role for nitric oxide in promoting mitochondrial synthesis may be the reason why.

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Figure 1: In white adipose tissue and other mouse tissues, caloric restriction (CR) induces cGMP production through an increase in eNOS levels.

Rebecca Henretta


  1. McCay, C.M., Cromwell, M.F. & Maynard, L.A. J. Nutr. 10, 63–79 (1935).

    CAS  Article  Google Scholar 

  2. Lin, S.J., Defossez, P.-A. & Guarente, L. Science 289, 2126–2128 (2000).

    CAS  Article  Google Scholar 

  3. Guarente, L. & Picard, F. Cell 120, 473–482 (2005).

    CAS  Article  Google Scholar 

  4. Nisoli, E. et al. Science 310, 314–317 (2005).

    CAS  Article  Google Scholar 

  5. Moncada, S., Palmer, R. & Higgs, E.A. Pharmacol. Rev. 43, 109–142 (1991).

    CAS  PubMed  Google Scholar 

  6. Lin, S.J. et al. Nature 418, 344–348 (2002).

    CAS  Article  Google Scholar 

  7. Luo, J. et al. Cell 107, 137–148 (2001).

    CAS  Article  Google Scholar 

  8. Bordone, L. & Guarente, L. Nat. Rev. Mol. Cell Biol. 6, 298–305 (2005).

    CAS  Article  Google Scholar 

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Guarente, L. NO link between calorie restriction and mitochondria. Nat Chem Biol 1, 355–356 (2005).

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