An autocatalytic network for ribozyme self-construction

The emergence of a primordial RNA world would have required the formation of RNA polymers of sufficient length to possess catalytic activities, which are difficult to obtain by spontaneous polymerization. An analysis of an autocatalytic assembly pathway that can self-construct a functioning ribozyme from smaller oligonucleotide building blocks describes a potential route for RNA extension.

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Figure 1: Model for the emergence of complex ribozymes in an RNA world.


  1. 1

    Gilbert, W. Nature 319, 618 (1986).

    Article  Google Scholar 

  2. 2

    Nissen, P. et al. Science 289, 920–930 (2000).

    CAS  Article  Google Scholar 

  3. 3

    Cech, T.R. Biosci. Rep. 10, 239–261 (1990).

    CAS  Article  Google Scholar 

  4. 4

    Chen, X., Li, N. & Ellington, A.D. Chem. Biodivers. 4, 633–655 (2007).

    CAS  Article  Google Scholar 

  5. 5

    Hayden, E.J., von Kiedrowski, G. & Lehman, N. Angew. Chem. Int. Ed. Engl. published online, doi:10.1002/anie.200802177 (9 September 2008).

  6. 6

    Ferris, J.P., Hill, A.R. Jr., Liu, R. & Orgel, L.E. Nature 381, 59–61 (1996).

    CAS  Article  Google Scholar 

  7. 7

    Doudna, J.A., Couture, S. & Szostak, J.W. Science 251, 1605–1608 (1991).

    CAS  Article  Google Scholar 

  8. 8

    Hayden, E.J. & Lehman, N. Chem. Biol. 13, 909–918 (2006).

    CAS  Article  Google Scholar 

  9. 9

    Eigen, M. Naturwissenschaften 58, 465–523 (1971).

    CAS  Article  Google Scholar 

  10. 10

    Ludlow, R.F. & Otto, S. Chem. Soc. Rev. 37, 101–108 (2008).

    CAS  Article  Google Scholar 

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Seelig, B. An autocatalytic network for ribozyme self-construction. Nat Chem Biol 4, 654–655 (2008).

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