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Small molecules can have big effects on endurance

Nature Chemical Biology volume 4, pages 583584 (2008) | Download Citation

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Adaptation of muscle to endurance exercise training involves the coordinated expression of genes involved in oxidative metabolism, resulting in increased endurance. A recent study shows that small-molecule activators of two pathways thought to transduce these effects can enhance the effects of training, or even substitute for it.

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Affiliations

  1. Keith Baar and D. Grahame Hardie are in the Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.  d.g.hardie@dundee.ac.uk

    • Keith Baar
    •  & D Grahame Hardie

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DOI

https://doi.org/10.1038/nchembio1008-583

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