Adaptation of muscle to endurance exercise training involves the coordinated expression of genes involved in oxidative metabolism, resulting in increased endurance. A recent study shows that small-molecule activators of two pathways thought to transduce these effects can enhance the effects of training, or even substitute for it.
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Katie Ris-Vicari
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Baar, K., Hardie, D. Small molecules can have big effects on endurance. Nat Chem Biol 4, 583–584 (2008). https://doi.org/10.1038/nchembio1008-583
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DOI: https://doi.org/10.1038/nchembio1008-583
