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New mechanism for a classic folate inhibitor

Nature Chemical Biology volume 4, pages 581582 (2008) | Download Citation

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Metabolomics reveals new insights into the mechanism of an antimicrobial agent and folate metabolism.

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References

  1. 1.

    & Am. J. Clin. Nutr. 83, 993–1016 (2006).

  2. 2.

    & Annu. Rev. Nutr. 28, 313–329 (2008).

  3. 3.

    & Goodman and Gilman's The Pharmacological Basis of Therapeutics 10th edn, 1176–1179 (McGraw-Hill, New York, 2001).

  4. 4.

    et al. Nat. Chem. Biol. 4, 602–608 (2008).

  5. 5.

    et al. Proc. Natl. Acad. Sci. USA 98, 7152–7157 (2001).

  6. 6.

    , , , & Biochemistry 46, 6026–6042 (2007).

  7. 7.

    Nat. Rev. Drug Discov. 4, 594–610 (2005).

  8. 8.

    , , & PLoS Biol. 4, e351 (2006).

  9. 9.

    , & Nat. Protoc. 3, 1328–1340 (2008).

Download references

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Affiliations

  1. H. Alex Brown is Professor of Pharmacology and Chemistry at Vanderbilt University School of Medicine, 23rd Avenue South at Pierce, Nashville, Tennessee 37232-6600, USA.  alex.brown@vanderbilt.edu

    • H Alex Brown

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DOI

https://doi.org/10.1038/nchembio1008-581

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