D-Amino acids can be useful building blocks for pharmaceuticals, but synthesizing them at a low cost remains challenging. A good catalyst for generating unnatural D-amino acids has been created by expanding the substrate range of a highly specific dehydrogenase.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Katie Ris
References
Williams, R.M. Synthesis of Optically Active α-Amino Acids (Pergamon, Oxford, 1989).
Vedha-Peters, K., Gunawardana, M., Rozzell, J.D. & Novick, S.J. J. Am. Chem. Soc. 128, 10923–10929 (2006).
Hsu, C.-C., Hong, Z., Wada, M., Franke, D. & Wong, C.-H. Proc. Natl. Acad. Sci. USA 102, 9122–9126 (2005).
May, O., Nguyen, P.T. & Arnold, F.H. Nat. Biotechnol. 18, 317–320 (2000).
Carr, R. et al. Angew. Chem. Int. Edn Engl. 42, 4807–4810 (2003).
Hoffmeister, D., Yang, J., Liu, L. & Thorson, J.S. Proc. Natl. Acad. Sci. USA 100, 13184–13189 (2003).
Cirilli, M., Scapin, G., Sutherland, A., Vederas, J.C. & Blanchard, J.S. Protein Sci. 9, 2034–2037 (2000).
Morley, K.L. & Kazlauskas, R.J. Trends Biotechnol. 23, 231–237 (2005).
DeLano, W.L. The PyMOL Molecular Graphic System. (DeLano Scientific LLC, South San Francisco, California, USA, 2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kazlauskas, R. Engineering a multipurpose catalyst. Nat Chem Biol 2, 514–515 (2006). https://doi.org/10.1038/nchembio1006-514
Issue Date:
DOI: https://doi.org/10.1038/nchembio1006-514
