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Breaking the silence in Friedreich's ataxia

A histone deacetylase inhibitor seems to restore the transcriptional activity of a silenced gene by overcoming heterochromatin effects, thereby offering a potential treatment for the neurodegenerative disease Friedreich's ataxia.

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Figure 1: Putative pathway whereby the new HDAC inhibitor may reverse silencing in cells from people with Friedreich's ataxia.


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Festenstein, R. Breaking the silence in Friedreich's ataxia. Nat Chem Biol 2, 512–513 (2006).

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