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Flipping the safety catch of procaspase-3

Caspase-3 is a central player in the orchestration of apoptotic cell death. A newly identified compound selectively activates caspase-3, has proapoptotic activity against transformed cells and retards the growth of procaspase-3–rich tumors.

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Figure 1: Summary of cell death pathways that converge on the proteolytic activation of caspase-3.

Katie Ris


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Porter, A. Flipping the safety catch of procaspase-3. Nat Chem Biol 2, 509–510 (2006).

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