Caspase-3 is a central player in the orchestration of apoptotic cell death. A newly identified compound selectively activates caspase-3, has proapoptotic activity against transformed cells and retards the growth of procaspase-3–rich tumors.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Katie Ris
References
Putt, K.S. et al. Nat. Chem. Biol. 2, 543–550 (2006).
Fuentes-Prior, P. & Salvesen, G. Biochem. J. 384, 201–232 (2004).
Shiozaki, E.N. & Shi, Y. Trends Biochem. Sci. 29, 486–494 (2004).
Roy, S. et al. Proc. Natl. Acad. Sci. USA 98, 6132–6137 (2001).
Fischer, U. & Schulze-Osthoff, K. Cell Death Differ. 12 (suppl. 1), 942–961 (2005).
Devarajan, E. et al. Oncogene 21, 8843–8851 (2002).
Schimmer, A.D. et al. Cancer Cell 5, 25–35 (2004).
Wu, T.Y.H. et al. Chem. Biol. 10, 759–767 (2003).
Buckley, C.D. et al. Nature 397, 534–539 (1999).
Garrido, C. & Kroemer, G. Curr. Opin. Cell Biol. 16, 639–646 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Porter, A. Flipping the safety catch of procaspase-3. Nat Chem Biol 2, 509–510 (2006). https://doi.org/10.1038/nchembio1006-509
Issue Date:
DOI: https://doi.org/10.1038/nchembio1006-509
This article is cited by
-
Heat stress impairs mice granulosa cell function by diminishing steroids production and inducing apoptosis
Molecular and Cellular Biochemistry (2016)
-
Hesperidin ameliorates trichloroethylene-induced nephrotoxicity by abrogation of oxidative stress and apoptosis in wistar rats
Molecular and Cellular Biochemistry (2015)
