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Se-ing into selenocysteine biosynthesis

A cocrystal structure of the enzyme that synthesizes selenocysteine reveals the elegantly simple recognition mechanism for the tRNA molecule for this '21st amino acid'. The structure resolves some mechanistic questions and allows for comparison of the tRNA-dependent synthesis of cysteine and selenocysteine.

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Figure 1: Synthesis of selenocysteine by SepSecS.


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Mueller, E. Se-ing into selenocysteine biosynthesis. Nat Chem Biol 5, 611–612 (2009).

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