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Taking the chemical out of chemical genetics

Screening a library of expressed cyclic peptides identified clones that reverse the cytotoxicity of α-synuclein in yeast and Caenorhabditis elegans. The results suggest a new approach for intervention in Parkinson's disease, and perhaps a druggable target.

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Figure 1: Arrayed versus expressed chemical genetics.


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Competing interests

C.P.S. is an inventor on US patent 7,354,756 entitled "Intein mediated cyclization of peptides."

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Scott, C. Taking the chemical out of chemical genetics. Nat Chem Biol 5, 609–610 (2009).

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