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A division of labor: asymmetric roles for GPCR subunits in receptor dimers

The functional architecture of dimeric or oligomeric GPCR signaling remains incompletely understood. Using a clever combination of receptor–G protein fusions and various receptor mutations, new research provides a glimpse into how oligomers might be arranged with respect to the G proteins they interact with.

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Figure 1: Asymmetry of receptor subunits in dimeric GPCRs.


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Correspondence to Terence E Hébert.

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Zylbergold, P., Hébert, T. A division of labor: asymmetric roles for GPCR subunits in receptor dimers. Nat Chem Biol 5, 608–609 (2009).

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