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Protease dimer formation disrupted

A small-molecule inhibitor of the obligate dimeric protease of human Kaposi's sarcoma–associated herpesvirus was identified. The agent functions by a 'monomer trap' mechanism in which the compound binds to a partially unfolded monomer and disrupts the formation of the enzymatically active protease dimer.

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Chmielewski, J. Protease dimer formation disrupted. Nat Chem Biol 5, 607–608 (2009).

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