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20S ways to apoptosis

Chemical inhibitors of the proteasome have received substantial attention owing to the success of bortezomib in the treatment of multiple myeloma. A recent whole-cell screen identified the proteasome inhibitor argyrin A and suggests a new role for p27Kip-1 in regulating apoptosis.

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Figure 1: Mechanisms of tumor growth inhibition by argyrin A.

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McConkey, D. 20S ways to apoptosis. Nat Chem Biol 4, 528–529 (2008). https://doi.org/10.1038/nchembio0908-528

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