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Cross-dressing proteins by olefin metathesis

Nature Chemical Biology volume 4, pages 527528 (2008) | Download Citation

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Chemists have established numerous methods for performing protein conjugations, but metathesis catalysts have largely remained absent from this toolkit. Evidence that proteins bearing allylsulfides undergo cross-metathesis with chosen alkenes in aqueous conditions will allow chemists to harness the power of metathesis catalysts for modifying biomolecules and other water-soluble compounds.

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Affiliations

  1. Kent Kirshenbaum and Paramjit S. Arora are in the Department of Chemistry, New York University, 100 Washington Square East, New York, New York 10003, USA.  kent@nyu.edu or arora@nyu.edu

    • Kent Kirshenbaum
    •  & Paramjit S Arora

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DOI

https://doi.org/10.1038/nchembio0908-527

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