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Cross-dressing proteins by olefin metathesis

Chemists have established numerous methods for performing protein conjugations, but metathesis catalysts have largely remained absent from this toolkit. Evidence that proteins bearing allylsulfides undergo cross-metathesis with chosen alkenes in aqueous conditions will allow chemists to harness the power of metathesis catalysts for modifying biomolecules and other water-soluble compounds.

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Figure 1: Two approaches for site-specifically adorning proteins with desired functionalities.


  1. Lin, Y.A., Chalker, J.M., Floyd, N., Bernardes, G.J.L. & Davis, B.G. J. Am. Chem. Soc. 130, 9642–9643 (2008).

    Article  CAS  Google Scholar 

  2. Bernardes, G.J.L., Chalker, J.M., Errey, J.C. & Davis, B.G. J. Am. Chem. Soc. 130, 5052–5053 (2008).

    Article  CAS  Google Scholar 

  3. Carrico, I.S. Chem. Soc. Rev. 37, 1423–1431 (2008).

    Article  CAS  Google Scholar 

  4. Laughlin, S.T., Baskin, J.M., Amacher, S.L. & Bertozzi, C.R. Science 320, 664–667 (2008).

    Article  CAS  Google Scholar 

  5. Binder, J.B., Blank, J.J. & Raines, R.T. Org. Lett. 9, 4885–4888 (2007).

    Article  CAS  Google Scholar 

  6. Jordan, J.P. & Grubbs, R.H. Angew. Chem. Int. Ed. 46, 5152–5155 (2007).

    Article  CAS  Google Scholar 

  7. Grubbs, R.H. Angew. Chem. Int. Ed. 45, 3760–3765 (2006).

    Article  CAS  Google Scholar 

  8. Hoveyda, A.H. et al. Org. Biomol. Chem. 2, 8–23 (2004).

    Article  CAS  Google Scholar 

  9. Saxon, E. & Bertozzi, C.R. Science 287, 2007–2010 (2000).

    Article  CAS  Google Scholar 

  10. Dieterich, D.C., Link, A.J., Graumann, J., Tirrell, D.A. & Schuman, E.M. Proc. Natl. Acad. Sci. USA 103, 9482–9487 (2006).

    Article  CAS  Google Scholar 

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Kirshenbaum, K., Arora, P. Cross-dressing proteins by olefin metathesis. Nat Chem Biol 4, 527–528 (2008).

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