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Charging the batteries to heal wounds through PI3K

Endogenous electric fields in wounds have been documented for centuries, but they have received little attention from the scientific community. A new study shows that manipulation of these electric fields affects wound healing in vivo and identifies the phosphoinositide 3-kinase signaling pathway as a key component of cell migration in response to electric cues.

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Figure 1: Action potential in individual cells and injury potential in tissues.

Katie Ris

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Vanhaesebroeck, B. Charging the batteries to heal wounds through PI3K. Nat Chem Biol 2, 453–455 (2006). https://doi.org/10.1038/nchembio0906-453

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