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Charging the batteries to heal wounds through PI3K

Endogenous electric fields in wounds have been documented for centuries, but they have received little attention from the scientific community. A new study shows that manipulation of these electric fields affects wound healing in vivo and identifies the phosphoinositide 3-kinase signaling pathway as a key component of cell migration in response to electric cues.

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Figure 1: Action potential in individual cells and injury potential in tissues.

Katie Ris


  1. 1

    Zhao, M. et al. Nature 442, 457–460 (2006).

    CAS  Article  Google Scholar 

  2. 2

    McCaig, C.D., Rajnicek, A.M., Song, B. & Zhao, M. Physiol. Rev. 85, 943–978 (2005).

    Article  Google Scholar 

  3. 3

    Ridley, A.J. et al. Science 302, 1704–1709 (2003).

    CAS  Article  Google Scholar 

  4. 4

    Comer, F.I. & Parent, C.A. Cell 109, 541–544 (2002).

    CAS  Article  Google Scholar 

  5. 5

    Fang, K.S., Ionides, E., Oster, G., Nuccitelli, R. & Isseroff, R.R. J. Cell Sci. 112, 1967–1978 (1999).

    CAS  PubMed  Google Scholar 

  6. 6

    Zhao, M., Pu, J., Forrester, J.V. & McCaig, C.D. FASEB J. 16, 857–859 (2002).

    CAS  Article  Google Scholar 

  7. 7

    Hirsch, E. et al. Thromb. Haemost. 95, 29–35 (2006).

    CAS  Article  Google Scholar 

  8. 8

    Braddock, M., Campbell, C.J. & Zuder, D. Int. J. Dermatol. 38, 808–817 (1999).

    CAS  Article  Google Scholar 

  9. 9

    Ojingwa, J.C. & Isseroff, R.R. J. Invest. Dermatol. 121, 1–12 (2003).

    CAS  PubMed  Google Scholar 

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Vanhaesebroeck, B. Charging the batteries to heal wounds through PI3K. Nat Chem Biol 2, 453–455 (2006).

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