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Form finds function

Assigning function to uncharacterized enzymes discovered through genome projects has provided a great challenge to the fields of informatics, enzymology and structural biology. Docking potential ligands into flexible models of protein structures and docking potential high-energy intermediates, rather than substrates, into known structures are two new computational approaches that have provided a much-needed boost to the field.

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Figure 1: Docking potential substrates to a flexible, threaded model.

Nicholas Silvaggi

Figure 2: Docking of high-energy intermediates to a crystal structure.

Nicholas Silvaggi

References

  1. Frazier, M.E. et al. Science 300, 290–293 (2003).

    Article  CAS  Google Scholar 

  2. Song, L. et al. Nat. Chem. Biol. 3, 486–491 (2007).

    Article  CAS  Google Scholar 

  3. Hermann, J.C. et al. Nature, published online 1 July 2007 (doi: 10.1038/nature05981).

    Article  CAS  Google Scholar 

  4. Babbitt, P.C. et al. Biochemistry 35, 16489–16501 (1996).

    Article  CAS  Google Scholar 

  5. Pauling, L. Chem. Eng. News 24, 1375–1377 (1946).

    Article  CAS  Google Scholar 

  6. Norvell, J.C. & Machalek, A.Z. Nat. Struct. Biol. 7 (Suppl.), 931 (2000).

    Article  CAS  Google Scholar 

Download references

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Allen, K. Form finds function. Nat Chem Biol 3, 452–453 (2007). https://doi.org/10.1038/nchembio0807-452

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  • DOI: https://doi.org/10.1038/nchembio0807-452

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