A new methodology combining small molecules and phage-displayed peptides enables the isolation of chemically modified bicyclic peptides capable of high-affinity recognition of target proteins.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Walsh, G. Nat. Biotechnol. 24, 769–776 (2006).
McCafferty, J., Griffiths, A.D., Winter, G. & Chiswell, D. Nature 348, 552–554 (1990).
Clackson, T., Hoogenboom, H.R., Griffiths, A.D. & Winter, G. Nature 352, 624–628 (1991).
Winter, G., Griffiths, A.D., Hawkins, R.E. & Hoogenboom, H.R. Annu. Rev. Immunol. 12, 433–455 (1994).
Kang, A.S., Barbas, C.F., Janda, K.D., Benkovic, S.J. & Lerner, R.A. Proc. Natl. Acad. Sci. USA 88, 4363–4366 (1991).
Heinis, C., Rutherford, T., Freund, S. & Winter, G. Nat. Chem. Biol. 5, 502–507 (2009).
Brenner, S. & Lerner, R.A. Proc. Natl. Acad. Sci. USA 89, 5381–5383 (1992).
Gartner, Z.J. et al. Science 305, 1601–1605 (2004).
Halpin, D.R. & Harbury, P.B. PLoS Biol. 2, E174 (2004).
Melkko, S., Scheuermann, J., Dumelin, C.E. & Neri, D. Nat. Biotechnol. 22, 568–574 (2004).
Mannocci, L. et al. Proc. Natl. Acad. Sci. USA 105, 17670–17675 (2008).
Smith, G.P. Science 228, 1315–1317 (1985).
Low, P.S., Henne, W.A. & Doorneweerd, D.D. Acc. Chem. Res. 41, 120–129 (2008).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
D.N. is a cofounder and shareholder of Philogen (www.philogen.com), a company that develops biotech products originating from phage display libraries and DNA-encoded chemical libraries.
Rights and permissions
About this article
Cite this article
Neri, D., Brändli, A. Encoding chemistry. Nat Chem Biol 5, 452–453 (2009). https://doi.org/10.1038/nchembio0709-452
Issue Date:
DOI: https://doi.org/10.1038/nchembio0709-452