Abstract
Drug discovery resources in academia and industry are not used efficiently, to the detriment of industry and society. Duplication could be reduced, and productivity could be increased, by performing basic biology and clinical proofs of concept within open access industry-academia partnerships. Chemical biologists could play a central role in this effort.
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References
Fingleton, B. Semin. Cell Dev. Biol. 19, 61–68 (2008).
Appels, N.M., Beijnen, J.H. & Schellens, J.H. Oncologist 10, 565–578 (2005).
Neeli, H. & Rader, D.J. Cardiol. Clin. 26, 537–546 (2008).
Boyce, S. & Hill, R.G. in Proceedings of the 9th World Congress on Pain (eds. Devor, M. et al.) 313–324 (International Association for the Study of Pain Press, Vienna, 2000).
Garnier, J.P. Harv. Bus. Rev. 86, 68–70, 72–76, 128 (2008).
Knight, Z.A. & Shokat, K.M. Cell 128, 425–430 (2007).
Newman, R.H. & Zhang, J. Nat. Chem. Biol. 4, 382–386 (2008).
Weigelt, J., McBroom-Cerajewski, L.D., Schapira, M., Zhao, Y. & Arrowmsmith, C.H. Curr. Opin. Chem. Biol. 12, 32–39 (2008).
Edwards, A. Annu. Rev. Biochem. 78, 541–568 (2009).
Kliewer, S.A., Lehmann, J.M. & Willson, T.M. Science 284, 757–760 (1999).
Chawla, A., Repa, J.J., Evans, R.M. & Mangelsdorf, D.J. Science 294, 1866–1870 (2001).
Willson, T.M. & Moore, J.T. Mol. Endocrinol. 16, 1135–1144 (2002).
Tamaoki, T. et al. Biochem. Biophys. Res. Commun. 135, 397–402 (1986).
Hirsch, J.E. Proc. Natl. Acad. Sci. USA 102, 16569–16572 (2005).
Menkes, C.J. et al. J. Rheumatol. 20, 714–717 (1993).
Marshall, K.W., Chiu, B. & Inman, R.D. Arthritis Rheum. 33, 87–90 (1990).
Babenko, V.V. et al. Eur. J. Pain 3, 93–102 (1999).
Jensen, K., Tuxen, C., Pedersen-Bjergaard, U. & Jansen, I. Cephalalgia 11, 175–182 (1991).
Pedersen-Bjergaard, U. et al. Peptides 10, 1147–1152 (1989).
Von Euler, U.S. in Neurotransmitters in Action (ed. Bousfield, D.) 143–150 (Elsevier Biomedical Press, Amsterdam, 1985).
Salt, T.E. & Hill, R.G. Neuroscience 10, 1083–1103 (1983).
Mantyh, P.W. et al. Science 278, 275–279 (1997).
Woolf, C.J. & Mannion, R.J. Lancet 353, 1959–1964 (1999).
Rupniak, N.M.J. & Hill, R.G. in Novel Aspects of Pain Management: Opioids and Beyond (eds. Sawynok, J. & Cowan, A.) 135–155 (Wiley-Liss, New York, 1999).
Gunthorpe, M.J. & Chizh, B. Drug Discov. Today 14, 56–67 (2009).
Gharat, L.A. & Szallasi, A. Expert Opin. Ther. Pat. 18, 159–209 (2008).
Acknowledgements
The authors thank C. Arrowsmith, I. Benjamin, D. Dodds, S. Frye, B. Greenberg, J. Weigelt, H. Widmer, T. Yamada and R. Young for comments on the paper. A.M.E. and C.B. are supported by the Structural Genomics Consortium, which is a registered charity (number 1097737) that receives funds from the Canadian Institutes for Health Research, the Canadian Foundation for Innovation, Genome Canada through the Ontario Genomics Institute, GlaxoSmithKline, Karolinska Institutet, the Knut and Alice Wallenberg Foundation, the Ontario Innovation Trust, the Ontario Ministry for Research and Innovation, Merck & Co., Inc., the Novartis Research Foundation, the Swedish Agency for Innovation Systems, the Swedish Foundation for Strategic Research and the Wellcome Trust.
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Edwards, A., Bountra, C., Kerr, D. et al. Open access chemical and clinical probes to support drug discovery. Nat Chem Biol 5, 436–440 (2009). https://doi.org/10.1038/nchembio0709-436
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DOI: https://doi.org/10.1038/nchembio0709-436
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