Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Modest membrane hydrogen bonds deliver rich results

Nature Chemical Biology volume 4, pages 393–394 (2008)Cite this article

The significance of hydrogen bonds in protein structure was recognized as early as 1936 by Mirsky and Pauling, and the importance of hydrogen bonds in water-soluble proteins has since been studied extensively. Now a new paper takes an important step forward in characterizing the energetic significance of hydrogen bonds in membrane-soluble proteins.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Energetics of potentially hydrogen bonding groups destined for membrane proteins or soluble protein cores.

References

  1. Albeck, S., Unger, R. & Schreiber, G. J. Mol. Biol. 298, 503–520 (2000).

    Article  CAS  Google Scholar 

  2. Joh, N.H. et al. Nature advance online publication, doi: 10.1038/nature06977 (25 May 2008).

  3. Rose, G.D. & Wolfenden, R. Annu. Rev. Biophys. Biomol. Struct. 22, 381–415 (1993).

    Article  CAS  Google Scholar 

  4. White, S.H. & Wimley, W.C. Annu. Rev. Biophys. Biomol. Struct. 28, 319–365 (1999).

    Article  CAS  Google Scholar 

  5. Engelman, D.M. et al. FEBS Lett. 555, 122–125 (2003).

    Article  CAS  Google Scholar 

  6. Lear, J.D., Gratkowski, H., Adamian, L., Liang, J. & DeGrado, W.F. Biochemistry 42, 6400–6407 (2003).

    Article  CAS  Google Scholar 

  7. Senes, A., Engel, D.E. & DeGrado, W.F. Curr. Opin. Struct. Biol. 14, 465–479 (2004).

    Article  CAS  Google Scholar 

  8. Horovitz, A. Fold. Des. 1, R121–R126 (1996).

    Article  CAS  Google Scholar 

  9. Rees, D.C., DeAntonio, L. & Eisenberg, D. Science 245, 510–513 (1989).

    Article  CAS  Google Scholar 

  10. Coleman, R.G. & Sharp, K.A. J. Mol. Biol. 362, 441–458 (2006).

    Article  CAS  Google Scholar 

  11. Pace, C.N. Biochemistry 40, 310–313 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Gevorg Grigoryan and William F. DeGrado are in the Department of Biochemistry & Biophysics, University of Pennsylvania School of Medicine, 1009 Stellar Chance Building, 36th and Hamilton Walk, Philadelphia, Pennsylvania 19104-6059, USA. wdegrado@mail.med.upenn.edu,

    Gevorg Grigoryan & William F DeGrado

Authors
  1. Gevorg Grigoryan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. William F DeGrado
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Grigoryan, G., DeGrado, W. Modest membrane hydrogen bonds deliver rich results. Nat Chem Biol 4, 393–394 (2008). https://doi.org/10.1038/nchembio0708-393

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio0708-393

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing