The significance of hydrogen bonds in protein structure was recognized as early as 1936 by Mirsky and Pauling, and the importance of hydrogen bonds in water-soluble proteins has since been studied extensively. Now a new paper takes an important step forward in characterizing the energetic significance of hydrogen bonds in membrane-soluble proteins.
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Grigoryan, G., DeGrado, W. Modest membrane hydrogen bonds deliver rich results. Nat Chem Biol 4, 393–394 (2008). https://doi.org/10.1038/nchembio0708-393
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DOI: https://doi.org/10.1038/nchembio0708-393