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Methuselah antagonist extends life span

Newly identified peptide antagonists of the GPCR Methuselah confirm the role of this receptor in aging and should prove useful as tools for investigating the physiological functions of this class of receptor.

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Figure 1: The ɛ subunit of F1F0 ATP synthase, Sun, is an agonist of Methuselah.


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McGarrigle, D., Huang, XY. Methuselah antagonist extends life span. Nat Chem Biol 3, 371–372 (2007).

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