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Chemical glycobiology: why now?

Understanding the structure and function of carbohydrates remains a key challenge for chemical biologists. Developments in carbohydrate synthesis and analysis together with the advent of high-throughput methods such as carbohydrate microarrays have helped shed light on the function of glycoconjugates. Similarly, consortia have provided technology platforms and focus to a burgeoning field. Now, recruitment of scientists from related fields and further integration of chemistry and biology to achieve technical goals are needed for rapid advancements.

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Figure 1: Carbohydrate complexity is a result of branching and the stereochemistry of the glycosidic linkage.
Figure 2: Strategies for carbohydrate synthesis.
Figure 3


  1. Kunz, H. Angew. Chem. Int. Ed. 41, 4439–4451 (2002).

    CAS  Article  Google Scholar 

  2. Varki, A. Glycobiology 3, 97–130 (1993).

    CAS  PubMed  Google Scholar 

  3. Seeberger, P.H. & Werz, D.B. Nature 446, 1046–1051 (2007).

    CAS  Article  PubMed  Google Scholar 

  4. Varki, A. et al. Essentials of Glycobiology (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, USA, 1999).

    Google Scholar 

  5. Boons, G.J. Carbohydrate Chemistry (Blackie Academic & Professional, Glasgow, Scotland, 1998).

    Google Scholar 

  6. Schmidt, R.R. Angew. Chem. Int. Edn Engl. 25, 212–235 (1986).

    Article  Google Scholar 

  7. Dell, A. & Morris, H.R. Science 291, 2351–2356 (2001).

    CAS  Article  PubMed  Google Scholar 

  8. Venkataraman, G., Shriver, Z., Raman, R. & Sasisekharan, R. Science 286, 537–542 (1999).

    CAS  Article  PubMed  Google Scholar 

  9. Plante, O.J., Palmacci, E.R. & Seeberger, P.H. Science 291, 1523–1527 (2001).

    CAS  Article  PubMed  Google Scholar 

  10. Sears, P. & Wong, C.-H. Science 291, 2344–2350 (2001).

    CAS  Article  PubMed  Google Scholar 

  11. Paulson, J.C., Blixt, O. & Collins, B.E. Nat. Chem. Biol. 2, 238–248 (2006).

    CAS  Article  PubMed  Google Scholar 

  12. Ohtsubo, K. & Marth, J.D. Cell 126, 855–867 (2006).

    CAS  Article  PubMed  Google Scholar 

  13. von der Lieth, C.-W. J. Carbohydr. Chem. 23, 277–297 (2004).

    CAS  Article  Google Scholar 

  14. Caruthers, M.H. Science 230, 281–285 (1985).

    CAS  Article  PubMed  Google Scholar 

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P.H.S. is a board member and major shareholder at Ancora Pharmaceuticals, a company he cofounded in 2003.

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Seeberger, P. Chemical glycobiology: why now?. Nat Chem Biol 5, 368–372 (2009).

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