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A gateway to study protein lysine methylation

Lysine methyltransferases are well-known regulators of transcription through their methylation of histone lysine residues. Now high-throughput peptide arrays reveal non-histone substrates of G9a/KMT3C, which was previously known as a euchromatic histone H3K9-specific methyltransferase.

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Figure 1: Identification of a G9 substrate consensus sequence and discovery of non-histone targets using SPOT.

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Trojer, P., Reinberg, D. A gateway to study protein lysine methylation. Nat Chem Biol 4, 332–334 (2008). https://doi.org/10.1038/nchembio0608-332

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