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Stopping replication, at the beginning

A new pharmacological inhibitor of the Cdc7 protein kinase can block replication initiation without activating the replication checkpoint, thus validating replication initiation as a new target class for cancer cell chemotherapy.

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Figure 1: Cdc7 regulation of DNA replication and checkpoints in normal and tumor cells.


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Jackson, P. Stopping replication, at the beginning. Nat Chem Biol 4, 331–332 (2008).

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