Stimulating the cell's appetite for itself

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New inducers of autophagy—the process by which cells use lysosomes to degrade portions of their cytoplasm—are lead compounds for new drugs targeting neurodegenerative protein aggregation diseases.

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Figure 1: SMERs as novel inducers of autophagy.

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Simonsen, A., Stenmark, H. Stimulating the cell's appetite for itself. Nat Chem Biol 3, 304–306 (2007) doi:10.1038/nchembio0607-304

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