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Stimulating the cell's appetite for itself

New inducers of autophagy—the process by which cells use lysosomes to degrade portions of their cytoplasm—are lead compounds for new drugs targeting neurodegenerative protein aggregation diseases.

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Figure 1: SMERs as novel inducers of autophagy.


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Simonsen, A., Stenmark, H. Stimulating the cell's appetite for itself. Nat Chem Biol 3, 304–306 (2007).

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