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Making carbon-nitrogen bonds in biological and chemical synthesis

Nature Chemical Biology volume 2, pages 284–287 (2006)Cite this article

The function of many biologically active molecules requires the presence of carbon-nitrogen bonds in strategic positions. The biosynthetic pathways leading to such bonds can be bypassed through chemical synthesis to synthesize natural products more efficiently and also to generate the molecular diversity unavailable in nature.

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Figure 1: Nitrogen-containing fragments are key to biological activity.
Figure 2
Figure 3: Oxygen transfer: monooxygenase versus synthetic catalysts.

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  1. the Department of Chemistry, Davenport Research Laboratories, University of Toronto, 80 St. George Street, Toronto, M5S 3H6, Ontario, Canada

    Ryan Hili & Andrei K Yudin

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  1. Ryan Hili
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  2. Andrei K Yudin
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Hili, R., Yudin, A. Making carbon-nitrogen bonds in biological and chemical synthesis. Nat Chem Biol 2, 284–287 (2006). https://doi.org/10.1038/nchembio0606-284

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