Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Breaking the barriers of translation

New data from single-molecule optical trapping methods provide exciting clues as to the underlying mechanism of ribosome translocation along mRNA and a powerful new approach for future investigations of translation regulation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Stepping of the ribosome through structured mRNA templates observed by single-molecule optical trapping methods.

References

  1. Tenson, T. & Mankin, A. Mol. Microbiol. 59, 1664–1677 (2006).

    Article  CAS  Google Scholar 

  2. Wilson, D.N. & Nierhaus, K.H. Crit. Rev. Biochem. Mol. Biol. 42, 187–219 (2007).

    Article  CAS  Google Scholar 

  3. Wen, J.-D. et al. Nature 452, 598–603 (2008).

    Article  CAS  Google Scholar 

  4. Vanzi, F., Vladimirov, S., Knudsen, C., Goldman, Y. & Cooperman, B. RNA 9, 1174–1179 (2003).

    Article  CAS  Google Scholar 

  5. Blanchard, S.C., Gonzalez, R.L., Kim, H.D., Chu, S. & Puglisi, J.D. Nat. Struct. Mol. Biol. 11, 1008–1014 (2004).

    Article  CAS  Google Scholar 

  6. Munro, J.B., Altman, R.B., O'Connor, N. & Blanchard, S.C. Mol. Cell 25, 505–517 (2007).

    Article  CAS  Google Scholar 

  7. Uemura, S. et al. Nature 446, 454–457 (2007).

    Article  CAS  Google Scholar 

  8. Ogle, J.M. & Ramakrishnan, V. Annu. Rev. Biochem. 74, 129–177 (2005).

    Article  CAS  Google Scholar 

  9. Korostelev, A. & Noller, H.F. Trends Biochem. Sci. 32, 434–441 (2007).

    Article  CAS  Google Scholar 

  10. Munro, J.B., Vaiana, A., Sanbonmatsu, K.Y. & Blanchard, S.C. Biopolymers 89, 565–577 (2008).

    Article  CAS  Google Scholar 

  11. Yusupova, G., Jenner, L., Rees, B., Moras, D. & Yusupov, M. Nature 444, 391–394 (2006).

    Article  CAS  Google Scholar 

  12. Namy, O., Rousset, J.P., Napthine, S. & Brierley, I. Mol. Cell 13, 157–168 (2004).

    Article  CAS  Google Scholar 

  13. Takyar, S., Hickerson, R.P. & Noller, H.G. Cell 120, 49–58 (2005).

    Article  CAS  Google Scholar 

  14. Qin, Y. et al. Cell 127, 721–733 (2006).

    Article  CAS  Google Scholar 

  15. Sanbonmatsu, K.Y., Joseph, S. & Tung, C.S. Proc. Natl. Acad. Sci. USA 102, 15854–15859 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Blanchard, S. Breaking the barriers of translation. Nat Chem Biol 4, 275–276 (2008). https://doi.org/10.1038/nchembio0508-275

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio0508-275

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing