Lysine methylation has been implicated in gene transcription and epigenetic control. Chemical modification of cysteine residues results in a highly similar structural and functional analog of methylated lysine and provides a means to study this important modification in nucleosomes.
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Acknowledgements
This work is supported by grants to P.R.T. from the US National Institutes of Health and the American Heart Association.
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Bhatia, M., Thompson, P. Methyllysine analogs: rewriting the code. Nat Chem Biol 3, 249–250 (2007). https://doi.org/10.1038/nchembio0507-249
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DOI: https://doi.org/10.1038/nchembio0507-249